Basic Facts About Prempro
- Name: Prempro Hormone Replacement Therapy
- Generic Conjugated Estrogen and Conjugated Medroxyprogesterone Acetate
- Manufacturer: Wyeth Pharmaceuticals
- Date Approved: November 1995
- Status: Prescription Only
- Approved Uses: Menopausal Symptoms
- Off-Label Use: Heart Disease Prevention
- Side Effects: Heart Disease, Breast Cancer, Ovarian Cancer, Stroke, Blood Clots, Dementia
What is Prempro?
Prempro is a prescription medication approved as a hormone replacement therapy for menopausal symptoms in women who still have their uterus. The drug contains a mixture of natural estrogen hormones as well as a progestin, a synthetic form or progesterone, a natural hormone. Pempro comes in tablet form and is taken once a day. Possible side effects of the drug, according to the manufacturer, Wyeth, are headaches, breast pain, and back pain.
Officially, Prempro is approved for the following uses:
- treating moderate to severe hot flashes due to menopause
- treating moderate to severe itching, burning, or dryness in and around the vagina due to menopause
- Preventing heart attacks in postmenopausal women
Prempro is only approved for women who still have a uterus (have not had a hysterectomy).
Treatment Regimen
Prempro, also known as estrogen/conjugated medroxyprogesterone acetate, was approved by the U.S. Food and Drug Administration (FDA) in November 1995, as a drug to relieve menopause symptoms and osteoporosis. It is a combination of two hormones–estrogen and progestin, and is used only by menopausal women who have not had hysterectomies. Prempro was the first approved medication for hormone replacement therapy (HRT), and is still one of the most common HRTs prescribed by physicians. In 2003, it was estimated that more than 10 million postmenopausal women in the U.S. took estrogen or the combination of estrogen and progestin products to treat symptoms of menopause. The typical treatment consists of one tablet (pill) containing 0.625 mg of estrogen and 2.5 mg of progestin daily.
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